Chromophore selective multi-wavelength photoacoustic remote sensing of unstained human tissues

Multi-Wavelength and Multi-Direction Remote Sensing of Atmospheric Aerosols and Clouds

Estimating chromophore distributions from multiwavelength photoacoustic images.

Biomedical photoacoustic tomography (PAT) can provide qualitative images of biomedical soft tissue with high spatial resolution. However, whether it is possible to give accurate quantitative estimates of the spatially varying concentrations of the sources of photoacoustic contrast-endogenous or exogenous chromophores-remains an open question. Even if the chromophores' absorption spectra are kno...

Multi-agent Remote Sensing Image Segmentation Algorithm

Due to fractal network evolution algorithm (FNEA) in the treatment of the high spatial resolution remote sensing image (HSRI) using a parallel global control strategies which limited when the objects in each cycle by traversal of and not good use the continuity of homogenous area on the space and lead to problems such as bad image segmentation, therefore puts forward the remote sensing image se...

Absolute measurements of local chromophore concentrations using pulsed photoacoustic spectroscopy

Photoacoustic spectroscopy has the potential to make non-invasive, spatially resolved measurements of absolute chromophore concentrations. This has a wide range of possible applications, for example the mapping of endogenous chromophores such as oxy(HbO2) and deoxyhaemoglobin (HHb) or externally administered contrast agents designed to target specific tissues or molecular processes. In this stu...

Fluorescence lifetime imaging of unstained tissues: early results in human breast cancer.

Fluorescence lifetime imaging (FLIM) depends on the fluorescence decay differences between tissues to generate image contrast. In the present study FLIM has been applied to fixed (but unstained) breast cancer tissues to demonstrate the feasibility of this approach for histopathological assessment. As the FLIM method relies on natural autofluorescence, it may be possible to circumvent tissue pro...